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Banned by some sports organisations. Drug interactions with immunosuppressants. Limited long-term data.
7-Keto DHEA is a non-hormonal DHEA metabolite that does not convert to sex hormones. Used for weight management, immune function, and anti-ageing.
Provides targeted nutritional substrate or pharmacological activity for specific biochemical pathways not adequately supported by standard dietary intake. Mechanism involves enzyme cofactor provision, receptor modulation, or membrane structural modification.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Possibly safe | — |
| Pregnancy | Possibly safe | — |
| Elderly | Possibly safe | — |
No peer-reviewed clinical trial data found for this ingredient.
Hormone antagonists
DHEA converts to oestrogen, potentially opposing tamoxifen's anti-oestrogenic effects in breast cancer.
Chemotherapy
7-Keto DHEA converts to sex hormones opposing hormone-blocking therapy
Immunosuppressants
Adrenal hormone interactions — DHEA counteracts glucocorticoid effects
Antidiabetics
DHEA may alter insulin sensitivity. Variable effects on blood glucose reported.
Anticoagulants
Sex hormone modulation alters coagulation factors
Antidepressants
DHEA modulates central monoamine systems
Data by supplement.ge — Public Health Institute of Georgia (PHIG)