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SAFE

Arginine Alpha-Ketoglutarate

AAKG (arginine + alpha-ketoglutarate)

Possibly Safe 7 PubMed studies PubChem 11427178 ↗

Contraindications & warnings

GI side effects. Herpes simplex: may provoke recurrence. Cardiovascular drug interaction.

About

Arginine with alpha-ketoglutarate for enhanced nitric oxide production and Krebs cycle support.

Mechanism of action

Enhances exercise performance via substrate provision, haemodynamic effects (vasodilation via nitric oxide), or anabolic/anti-catabolic signalling (mTOR activation). Reduces exercise-induced oxidative stress and inflammatory cytokine production.

Safety by population

Population Safety rating Max safe dose
General Possibly safe 3-6g/day
GI side effects. Herpes simplex: may provoke recurrence.

Effectiveness

No peer-reviewed clinical trial data found for this ingredient.

Medical disclaimer: This information is for educational purposes only. It does not constitute medical advice. Always consult a qualified healthcare professional before taking any supplement or changing your medication.

Data by supplement.ge — Public Health Institute of Georgia (PHIG)