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Generally well tolerated. Mild GI side effects. AKBA exhibits significant P-glycoprotein inhibition — may increase plasma levels of P-gp substrate drugs.
Resin extract from Boswellia trees containing boswellic acids, particularly AKBA (3-O-acetyl-11-keto-beta-boswellic acid). Strong evidence for osteoarthritis pain reduction.
AKBA is a potent and selective 5-lipoxygenase (5-LOX) inhibitor, blocking pro-inflammatory leukotriene synthesis. Inhibits cathepsin G. Reduces cartilage-degrading enzymes.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Possibly safe | — |
| Pregnancy | Possibly safe | — |
| Elderly | Possibly safe | — |
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)