PRESCRIPTION ONLY: Too potent for unsupervised supplement use. Narrow therapeutic index — hypercalcaemia and hypercalciuria risk at very small dose increases. Monitoring of serum calcium essential. NOT for supplement use.
Active hormonal form of Vitamin D. Used pharmaceutically for secondary hyperparathyroidism in CKD and hypoparathyroidism. Supplement use INAPPROPRIATE — very narrow therapeutic index.
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Possibly unsafe | — |
| Pregnancy | Possibly unsafe | — |
| Elderly | Possibly unsafe | — |
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)