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Leucovorin rescue: prescribed in methotrexate toxicity — distinguish from supplement use. Active folate — same general considerations as 5-MTHF. Does not mask B12 deficiency like folic acid. Drug interaction: methotrexate (used to rescue).
Reduced activated folate form. Used as leucovorin rescue in methotrexate therapy and as active folate supplement. Bypasses dihydrofolate reductase.
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Possibly safe | — |
| Pregnancy | Possibly safe | — |
| Elderly | Possibly safe | — |
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)