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Generally safe. A small Australian RCT (Hunne et al.) suggested irritability and restlessness in some children at high doses — requires confirmation. ADHD: some practitioner advice to avoid, though evidence is limited. Very safe at typical preservative quantities.
Calcium salt of propionic acid used as mould and rope inhibitor in baked goods. E282. GRAS. Metabolised as propionic acid (normal fermentation product). Some studies suggest effect on child behaviour at high doses.
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Possibly safe | — |
| Pregnancy | Possibly safe | — |
| Elderly | Possibly safe | — |
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)