Mildly laxative at high doses. May affect iron absorption. Caffeine-free in supplement form.
Chlorogenic acid is the primary polyphenol in coffee (unroasted) and artichoke. Used for blood sugar, blood pressure, and weight management.
Acts as direct free radical scavenger and indirect antioxidant via Nrf2/ARE pathway activation. Modulates inflammatory signalling via NF-kB and AP-1 inhibition. Interacts with kinase pathways (MAPK, PI3K/Akt, mTOR) and epigenetic regulators relevant to anti-ageing and disease prevention.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Likely safe | — |
| Pregnancy | Likely safe | — |
| Elderly | Likely safe | — |
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)