Generally safe at supplemental doses. Chromium picolinate form occasionally associated with DNA damage concerns in vitro — clinical significance uncertain. Theoretical interaction with antidiabetic medications (additive blood glucose lowering).
Chromium is a trace mineral that enhances insulin signalling. EU approved claim: contributes to normal macronutrient metabolism and maintenance of normal blood glucose levels.
Chromium-binding molecule called chromodulin (LMWCr) potentiates insulin receptor tyrosine kinase activity when chromium binds. Increases GLUT4 translocation to cell membranes.
| Population | Safety rating | Max safe dose |
|---|---|---|
| Diabetes | Possibly safe | 200-1000mcg/day with monitoring |
| Enhances insulin sensitivity. Monitor blood glucose closely. | ||
| General | Possibly safe | 200mcg/day |
| No established UL. Very low toxicity from picolinate form. High doses may cause kidney damage. | ||
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)