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SAFE

Citrulline Malate 2-1

Citrulline malate 2:1 ratio

Likely Safe 2,200 PubMed studies PubChem 162762 ↗

Contraindications & warnings

Very safe. Mild GI effects at above 10g. Very popular in pre-workout formulas.

About

Most studied sports form: 2 citrulline to 1 malate. For muscular endurance, blood flow, and delayed fatigue.

Mechanism of action

Enhances exercise performance via substrate provision, haemodynamic effects (vasodilation via nitric oxide), or anabolic/anti-catabolic signalling (mTOR activation). Reduces exercise-induced oxidative stress and inflammatory cytokine production.

Safety by population

Population Safety rating Max safe dose
General Likely safe 6-8g/day
Very safe. Mild GI effects above 10g.

Effectiveness

No peer-reviewed clinical trial data found for this ingredient.

Medical disclaimer: This information is for educational purposes only. It does not constitute medical advice. Always consult a qualified healthcare professional before taking any supplement or changing your medication.

Data by supplement.ge — Public Health Institute of Georgia (PHIG)