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Very safe. No significant drug interactions identified. Mild gastrointestinal effects possible at high doses. Safe alternative to arginine for NO-mediated vasodilation.
L-Citrulline is a non-essential amino acid that is converted to arginine in the kidneys, more efficiently raising plasma arginine than direct arginine supplementation. Evidence for blood pressure reduction, exercise performance, and erectile function.
Converted to arginine by ASS1 and ASL enzymes in kidneys and intestinal cells — bypasses first-pass hepatic metabolism of arginine. Arginine is then converted to nitric oxide by NOS. Citrulline malate combines with malic acid for additional ergogenic effect.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Likely safe | — |
| Pregnancy | Likely safe | — |
| Elderly | Likely safe | — |
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)