May worsen insulin resistance in type 2 diabetes. May increase inflammatory markers. GI side effects. Pregnancy: insufficient data.
CLA from safflower oil or dairy is a mixture of trans fatty acids with body composition (muscle/fat), anti-cancer, and metabolic effects.
Incorporated into cell membrane phospholipids altering membrane fluidity and lipid raft composition. Serve as precursors to specialised pro-resolving mediators (resolvins, protectins) that actively resolve inflammation. Activate PPAR nuclear receptors for metabolic gene transcription.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Possibly safe | — |
| Pregnancy | Possibly safe | — |
| Elderly | Possibly safe | — |
No peer-reviewed clinical trial data found for this ingredient.
Antidiabetic
May affect insulin sensitivity.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)