ANTICOAGULANT INTERACTION: potent antiplatelet effects — avoid with warfarin, aspirin, and other anticoagulants/antiplatelets. Drug interactions: CYP3A4 inhibition, P-gp inhibition, CYP1A2 inhibition. Iron chelation — reduces iron absorption. Hepatotoxicity reports (rare, mainly at very high doses). Gallstone disease: stimulates bile secretion — caution. Pregnancy: avoid concentrated extracts (uterine stimulant at high doses).
Primary curcuminoid from turmeric. Anti-inflammatory (NF-κB and COX-2 inhibition), antioxidant, and potential anti-cancer properties. Poor oral bioavailability without formulation technology. Very large number of clinical trials.
Potent NF-kB inhibitor (blocking IKK phosphorylation of IkBa). Inhibits COX-2 and 5-lipoxygenase. Activates Nrf2 and HO-1 antioxidant pathway. Inhibits VEGF-mediated angiogenesis. Chelates redox-active metals. Poor bioavailability requires piperine or phospholipid complex.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Likely safe | 8000mg/day |
| GRAS status. Piperine increases absorption and drug interactions. | ||
No peer-reviewed clinical trial data found for this ingredient.
Anticoagulant
Antiplatelet and anticoagulant properties; additive with warfarin.
Anticoagulant
Antiplatelet and anticoagulant properties. Piperine combination further complicates drug metabolism.
Management: Monitor INR. Stop 2 weeks before surgery.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)