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Leber disease/hereditary optic neuropathy: cyanocobalamin CONTRAINDICATED — cyanide component impairs mitochondrial function in this condition. Use methylcobalamin instead. Tobacco amblyopia: same caution. Otherwise very safe at supplement doses.
Synthetic B12 form most studied in clinical trials. Converted to active forms (methylcobalamin, adenosylcobalamin). Contains small cyanide moiety.
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Possibly safe | — |
| Pregnancy | Possibly safe | — |
| Elderly | Possibly safe | — |
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)