Calcium depletion: disodium EDTA chelates calcium — prefer calcium disodium EDTA form. High-dose IV chelation: dangerous (cardiac arrest risk) — unrelated to food preservative use. At food preservative quantities: calcium disodium EDTA very safe. Reduces mineral absorption (chelation) — take separately from mineral supplements.
Chelating agent used as preservative and antioxidant in food and pharmaceutical products. E385 (calcium disodium EDTA) permitted in certain foods. Calcium disodium form preferred to avoid calcium depletion. FDA-approved preservative.
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Possibly safe | — |
| Pregnancy | Possibly safe | — |
| Elderly | Possibly safe | — |
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)