EU mandatory warning: "May have an adverse effect on activity and attention in children." Potential cross-reactivity with aspirin. Allergic reactions: urticaria, angioedema, rhinitis. Norway banned it (later harmonised with EU). Avoid in children with ADHD, aspirin-sensitive individuals, and patients with chronic urticaria.
Synthetic azo dye (Sunset Yellow) used as orange-yellow food colouring. Part of Southampton Six hyperactivity-linked dyes. Cross-reactivity with aspirin. Associated with allergic reactions and hypersensitivity. EFSA re-evaluated safety 2009 but EU hyperactivity labelling requirement maintained.
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Possibly unsafe | — |
| Pregnancy | Possibly unsafe | — |
| Elderly | Possibly unsafe | — |
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)