Very safe. Does not cause UMFA accumulation. Does not require MTHFR conversion. Natural preferred form.
Food-matrix naturally-occurring folates in their tetrahydrofolate forms. Preferred over synthetic folic acid for MTHFR-variant individuals.
Converted to 5-MTHF which donates methyl groups to homocysteine via methionine synthase regenerating THF for thymidylate synthesis. Essential for cell division, DNA synthesis, and neural tube closure.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Likely safe | 1000mcg/day |
| UL 1000mcg/day synthetic folic acid. Food folate has no UL. | ||
| Pregnancy | Likely safe | 1000mcg/day |
| Essential to prevent neural tube defects. | ||
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)