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Hereditary fructose intolerance (HFI): ABSOLUTELY CONTRAINDICATED — life-threatening fructose metabolism disorder. GOUT: Fructose increases uric acid synthesis. Metabolic syndrome: very high fructose intake associated with non-alcoholic fatty liver disease (NAFLD), dyslipidaemia, insulin resistance. IBS/FODMAP: fructose malabsorption triggers GI symptoms in sensitive individuals.
Simple monosaccharide found naturally in fruits and honey. Used as sweetener and tablet excipient. Metabolised primarily in liver via fructokinase. High-dose fructose associated with metabolic syndrome.
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Possibly safe | — |
| Pregnancy | Possibly safe | — |
| Elderly | Possibly safe | — |
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)