Antiplatelet properties — stop 1 week before surgery. Garlic significantly reduces saquinavir plasma levels (HIV treatment) via CYP3A4 induction — contraindicated with saquinavir-based regimens.
Culinary plant with modest but consistent evidence for blood pressure reduction and cholesterol lowering. Allicin is the primary bioactive compound, formed when alliin is cleaved by alliinase on crushing.
Allicin inhibits platelet aggregation by blocking PAF receptors and thromboxane synthesis. Hydrogen sulfide (H2S) produced from allicin relaxes vascular smooth muscle, reducing BP. Inhibits HMG-CoA reductase.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Likely safe | No established UL |
| Breath odour. Mild antiplatelet effects. | ||
| Surgery | Possibly unsafe | Stop 2 weeks before surgery |
| Significant antiplatelet and anticoagulant effects. Multiple case reports of surgical bleeding. | ||
No peer-reviewed clinical trial data found for this ingredient.
Antiretroviral
Significantly reduces saquinavir plasma levels via CYP3A4 induction.
Antiretrovirals
CYP3A4 induction reduces saquinavir AUC by 51%
Anticoagulants
Antiplatelet (ajoene/allicin) + possible CYP2C9 inhibition — INR elevation
Antiplatelet drugs
Additive antiplatelet effect
Antihypertensives
Additive vasodilation
Antidiabetics
Allicin enhances insulin secretion — additive hypoglycemia
Data by supplement.ge — Public Health Institute of Georgia (PHIG)