SHELLFISH ALLERGY: derived from shellfish chitin — caution in shellfish-allergic individuals (allergen in chitin, not glucosamine itself, but caution warranted). Warfarin: well-documented interaction — INR increase reported; monitor INR. Blood glucose: mild insulin resistance effect in some studies — monitor in diabetes. Asthma: case reports of exacerbation. Prescription medicine in EU.
Aminosaccharide used for osteoarthritis management. Strong evidence from European RCTs (GUIDE study) for knee OA pain and radiological progression. Prescription medicine in most EU countries (Dona/Rottapharm). Shellfish-derived.
Acts on cellular signalling pathways relevant to the documented clinical indications. Contains bioactive compounds with enzyme-modulating, receptor-binding, or antioxidant properties studied in peer-reviewed literature.
| Population | Safety rating | Max safe dose |
|---|---|---|
| General | Possibly safe | — |
| Pregnancy | Possibly safe | — |
| Elderly | Possibly safe | — |
No peer-reviewed clinical trial data found for this ingredient.
Data by supplement.ge — Public Health Institute of Georgia (PHIG)